Loading patent…
OwnerThomas MALCOLM, Safia RIZVI +1inventors
InventorsThomas MALCOLM, Safia RIZVI, Surya SANKURATRI
Estimating the term…
Hypoimmunogenic induced pluripotent stem cell (iPSC)-derived biomimetic nanovesicles (Hypo-BioNVs) or Hypo-exosomes including tailored chimeric antigen receptor (CARs) which can recognize target biomarkers. A method of making Hypo-BioNVs. A method of treating an individual with cancer, by administering the Hypo-BioNVs to an individual, targeting cancer cells, and treating the cancer. Hypo-BioNVs including tailored CARs which can recognize target biomarkers through a VERR including viral receptors of an oncolytic virus. A method of treating an individual with cancer, by administering Hypo-BioNVs including CAR receptors to an individual, targeting cancer cells, and treating the cancer. A method of targeting cells in an individual, by administering the Hypo-BioNVs to an individual, and targeting cells to be destroyed or treated for cancer tumors (both liquid and solid), infectious disease, hereditary conditions, autoimmune disease, or metabolic disorders.
A method of generating allogenic biomimetic nanovesicles (BioNVs) from gene edited iPSCs including the steps of:
A composition comprising a therapeutic agent packaged in a hypo-BioNV, wherein said therapeutic agent is chosen from the group consisting of DNA, plasmid DNA, RNA, protein, small molecule, and combinations thereof.
A method of treating an individual with cancer, an infectious disease, or hereditary disease, including the steps of:
A method of treating a central nervous system (CNS) disease, including the steps of:
Dependencies are inferred from the claim text.