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US 2023/0144580 A1Published application
Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
AssigneeThe Feinstein Institutes for Medical Research
InventorKirk R. MANOGUE
Life of this patent
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Abstract
Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.
Claims30
A system for accelerating clot formation at an injury site of a patient using non-invasive electrical stimulation, the system comprising:
- an apparatus configured to be worn upon a portion of a head and/or neck of a patient, wherein
- the apparatus comprises at least two electrodes, and
- when the apparatus is worn by the patient,
- a first electrode of the at least two electrodes is disposed in a region of a branch of the trigeminal nerve, and
- a second electrode of the at least two electrodes is disposed in a region of a branch of the vagus nerve;
- and
- a controller in electrical communication with the at least two electrodes, the controller being configured to deliver, via the apparatus, electrical stimulation for accelerating clot formation, wherein
- the electrical stimulation comprises, over a time period of at least five minutes, applying electrical trigeminal nerve stimulation (TNS) pulses to the trigeminal nerve via the first electrode, and
- simultaneous with, overlapping with, and/or near-overlapping with application of the electrical TNS pulses, applying electrical vagal nerve stimulation (VNS) pulses to the vagus nerve via the second electrode, and
- the electrical stimulation is configured to significantly accelerate clot formation at an injury site of the patient.
7 more elements
A method for accelerating clot formation, comprising:
- providing an apparatus to be worn upon a portion of a head and/or neck of a patient, the apparatus comprising at least two electrodes, wherein, when the apparatus is worn by the patient,
- a first electrode of the at least two electrodes is disposed in a region of a branch of the trigeminal nerve, and
- a second electrode of the at least two electrodes is disposed in a region of a branch of the vagus nerve;
- and
- delivering, via a controller in electrical communication with the at least two electrodes, electrical stimulation for accelerating clot formation, wherein
- the electrical stimulation comprises, over a time period of at least five minutes,
- applying electrical trigeminal nerve stimulation (TNS) pulses to the trigeminal nerve via the first electrode, and
- simultaneous with, overlapping with, and/or near-overlapping with application of the electrical TNS pulses, applying electrical vagal nerve stimulation (VNS) pulses to the vagus nerve via the second electrode, and
- the electrical stimulation is configured to significantly accelerate clot formation at a current or future injury site of the patient.
6 more elements
Dependencies are inferred from the claim text.