Method of long-term preservation of chemical and biological species using sugar glasses
AssigneeMcMaster University
InventorsVincent Ho Yin Leung, Sana Jahanshahi-Anbuhi, Carlos Filipe, M. Monsur Ali
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Abstract
A method of preserving one or more chemical and/or biological species in a polymer matrix comprising pullulan and trehalose is described. The method includes combining the one or more chemical and/or biological species, an aqueous pullulan and a trehalose solution and drying the resultant mixture to provide a solid polymeric matrix in the form of a powder and/or with a water content of less than 10 wt %. The polymeric matrix comprising the one or more chemical and/or biological species and its use, for example, in biological preparations and medicaments is also described.
Claims23
A polymer matrix comprising pullulan and trehalose and one or more chemical and/or biological species, wherein the one or more chemical and/or biological species are incorporated within the polymer matrix and the polymer matrix preserves and/or stabilizes the one or more chemical and/or biological species, and the polymer matrix is in powder form.
A method of preserving and/or stabilizing one or more chemical and/or biological species comprising:
- a. combining the one or more chemical and/or biological species, pullulan and trehalose and water to provide a mixture;
- b. drying the mixture to form a polymer matrix which preserves and/or stabilizes the one or more chemical and/or biological species;
- and
- c. converting the polymer matrix into powder form.
16-22. (canceled Herein)
26-27. (canceled Herein)
A method of making and/or storing and/or transporting a stabilized medicament or component thereof comprising a) producing a mixture of pullulan, trehalose and one or more chemical and/or biological species, b) drying the mixture to 10 wt % moisture content or below to provide a dried material and c) packaging the dried material in a sealed container.
29-32. (canceled Herein)
Dependencies are inferred from the claim text.