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US 2023/0144544 A1Published application
Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
AssigneeNuvOx Pharma LLC
InventorEvan C. Unger
Life of this patent
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Abstract
A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
Claims21
1-25. (canceled)
A method of treating glioblastoma by multi-fraction radiotherapy or chemotherapy, comprising:
- concomitantly or up to 120 minutes prior to each fraction of radiation therapy or concomitantly with chemotherapy, administering to a subject suffering from glioblastoma a water emulsion of perfluoropentane to the mammal, wherein the perfluoropentane emulsion comprises a fluorosurfactant and about 1% to 10% w/vol of perfluoropentane;
- and
- simultaneously administering to said mammal carbogen or supplemental oxygen,
- wherein the perfluoropentane emulsion is administered at a dosage in the range from about 0.05 cc/kg to about 0.3 cc/kg.
1 more element
A method of treating solid hypoxic tumors by multi-fraction radiotherapy, comprising administering to a subject suffering from a solid hypoxic tumor, concomitantly or up to 120 minutes prior to each fraction of radiation therapy, a water emulsion of perfluoropentane to the mammal, wherein
- the perfluoropentane emulsion comprises a fluorosurfactant and about 1% to 10% w/vol of perfluoropentane, and
- the solid hypoxic tumor is selected from pancreatic cancer, non-small cell lung cancer, cervical carcinoma, squamous cell carcinoma, ovarian cancer, sarcoma, multiple myeloma, prostate cancer, rectal cancer, Wilms tumor, head and neck cancer, oral carcinoma and uterine carcinoma.
Dependencies are inferred from the claim text.