Shedding blocking agents with increased stability
AssigneeBiond Biologics Ltd.
InventorsMotti HAKIM, Anna FRIDMAN-DROR, Ilana MANDEL, Tehila BEN-MOSHE, Yair SAPIR, Avidor SHULMAN, Lilach Chen ZELTSBURG, Ayala LEWKOWICZ
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Abstract
Agents comprising at least two moieties separated by a linker, wherein a first moiety binds mCD28 on a surface of a cell and inhibits proteolytic cleavage of the mCD28 and wherein a second moiety increases stability of the first moiety are provided. Methods of treating cancer and improving immunotherapy comprising administering the agents are also provided.
Claims46
An agent comprising at least two moieties separated by a linker, wherein a first moiety binds membranal CD28 (mCD28) on a surface of a cell and inhibits proteolytic cleavage of said mCD28 and wherein a second moiety increases stability of said first moiety.
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Dependencies are inferred from the claim text.