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US 2023/0144322 A1Published application
18f-labeled psma-targeted pet imaging agents
AssigneesCancer Targeted Technology LLC, Washington State University
InventorsClifford Berkman, Svetlana A. Stekhova
Life of this patent
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Abstract
Compounds of Marlush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds. Representative compounds according to the application are:
Claims39
A compound of formula (I),
- or a pharmaceutically acceptable salt thereof, wherein
- L is a linker comprising a moiety of the formula —NH—CH2CH2—(OCH2CH2)y—C(O)— or a group of the formula
- wherein
- y is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
- m is 1, 2, 3, or 4;
- each n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
- R1 is phenyl or pyridyl;
- wherein the phenyl or pyridyl is substituted with an [F]- or [18F]-fluoro group and optionally substituted with a second group selected from halogen, cyano, and nitro;
- each R2 is independently hydrogen or C1-C6 alkyl;
- and
- each R is independently hydrogen or a protecting group;
- provided that when L is a group of the formula
- m·(n+2) is greater than or equal to 3 and less than or equal to 21.
10 more elements
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A compound of formula (U)
- or a pharmaceutically acceptable salt thereof, wherein
- L is a linker comprising a moiety of the formula —NH—CH2CH2—(OCH2CH2—)y—C(O)— or a group of the formula
- wherein
- y is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
- m is 1, 2, 3, or 4;
- each n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
- R1 is phenyl or pyridyl, wherein the phenyl or pyridyl is substituted with an [F]- or [18F]-fluoro group and optionally substituted with a second group selected from halogen, cyano, and nitro;
- each R2 is independently hydrogen or C1-C6 alkyl;
- and
- each R is independently hydrogen or a protecting group;
- provided that when L is a group of the formula
- m·(n+2) is greater than or equal to 3 and less than or equal to 21.
9 more elements
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Dependencies are inferred from the claim text.