Back to results
US 2023/0144237 A1Published application
Engineered cells and uses thereof
AssigneeNanjing Legend Biotech Co., Ltd.
InventorsZhongyuan Tu, Hezhong Zhang, Yafeng Zhang, Shu Wu
Life of this patent
Estimating the term…
Abstract
The present disclosure provides systems for inducing activity of immune cells and methods of immunotherapy. Systems of the present disclosure for inducing immune cell activity comprise a chimeric antigen receptor, a T cell receptor, and various combinations thereof.
Claims30
A system for inducing activity of an immune cell, comprising:
- (a) a chimeric antigen receptor (CAR) comprising a first antigen binding domain which exhibits specific binding to a first epitope, a transmembrane domain, and an intracellular signaling domain devoid of a signaling domain of CD3 zeta;
- and
- (b) a modified T cell receptor (TCR) complex comprising a second antigen binding domain that exhibits specific binding to a second epitope, wherein said second antigen binding domain is linked to:
- (i) at least one TCR chain selected from an alpha chain, a beta chain, a gamma chain, and a delta chain of a T cell receptor,
- (ii) an epsilon chain, a delta chain, and/or a gamma chain of cluster of differentiation 3 (CD3), or
- (iii) a CD3 zeta chain.
3 more elements
(canceled)
(canceled)
(canceled)
(canceled)
-24. (canceled)
-33. (canceled)
-65. (canceled)
-79. (canceled)
A composition comprising one or more polynucleotides that encodes:
- (a) a chimeric antigen receptor (CAR) comprising a first antigen binding domain having binding specificity for a first epitope, a transmembrane domain, and an intracellular signaling domain that is devoid of signaling domain of CD3 zeta;
- and
- (b) a modified T cell receptor (TCR) complex comprising a second antigen binding domain which exhibits specific binding to a second epitope, wherein said second antigen binding domain is linked to:
- (i) at least one TCR chain selected from an alpha chain, a beta chain, a gamma chain, and a delta chain of a T cell receptor,
- (ii) an epsilon chain, a delta chain, and/or a gamma chain of cluster of differentiation 3 (CD3), or
- (iii) a CD3 zeta chain.
3 more elements
-82. (canceled)
(canceled)
Dependencies are inferred from the claim text.