Preparation method of thermosensitive gel for treating androgenetic alopecia

Abstract

The present disclosure provides a preparation method of a thermosensitive gel for treating androgenetic alopecia. The preparation method includes the following steps: step 1, separating umbilical cord mesenchymal stem cells (UC-MSCs); step 2, conducting adherent culture of the UC-MSCs; step 3, preparing a lyophilized powder of umbilical cord-mesenchymal stem cell-conditioned medium (UC-MSC-CM) supernatant; and step 4, preparing the thermosensitive gel. In the present disclosure, the thermosensitive gel is prepared by using the UC-MSC-CM supernatant. Based on an important role of cytokines encapsulated in exosomes secreted by the UC-MSCs in the hair growth process, the exosomes are encapsulated in the thermosensitive gel for topical use in treating androgenetic alopecia, featuring easy operation, convenient treatment, and excellent efficacy.

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