Growth differentiation factor 15 fusion proteins
AssigneeAmgen Inc.
InventorsYuMei XIONG, Kenneth William WALKER, Murielle Marie VENIANT ELLISON
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Abstract
GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.
Claims24
A fusion protein comprising a GDF15 region joined to an Fc region via a linker, wherein the GDF15 region comprises the amino acid sequence of SEQ ID NO:
- 6 and at least one mutation, wherein at least one of the mutations is of the aspartate at position 5.
(canceled)
(canceled)
A fusion protein comprising a GDF15 region joined to an Fc region via a linker, wherein the GDF15 region comprises the amino acid sequence of SEQ ID NO:
- 6 and at least one mutation, wherein at least one of the mutations is of the asparagine at position 3 or the aspartate at position 5, and wherein the linker is a (G4Q)n linker and n is greater than 2.
(canceled)
(canceled)
The fusion protein of 9, wherein the Fc region comprises a truncated hinge region.
The fusion protein of 9, wherein the Fc region is selected from Table 3.
Dependencies are inferred from the claim text.