Colloidal carrier systems for transfer of agents to a desired site of action
AssigneeHeidelberg University
InventorsGert Fricker, Ulrike Müller, Tobias Köthe, Vicky Steubler, Susanne Katharina Klein
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Abstract
The present invention relates to a drug delivery composition comprising colloidal drug carriers, the composition and a polypeptide for use as a medicament, and in the treatment of neural and neurovascular diseases such as Alzheimer's diseases, and the use of colloidal drug carriers for the production of a drug delivery composition.
Claims17
Drug delivery composition comprising colloidal drug carriers selected from the group comprising nanoparticles and liposomes, and an agent,
- wherein the colloidal drug carriers are surface modified for active targeting to the desired site of action, and
- wherein the agent is a protein or polypeptide.
Use of colloidal drug carriers selected from the group comprising nanoparticles and liposomes for the production of a drug delivery composition comprising agents, preferably peptides or proteins, which are more preferably targeted to the central nervous system.
Polypeptide comprising the sequence of SEQ ID No. 3 and/or a sequence being at least 80% identical to SEQ ID No. 3 for use as a medicament, wherein the polypeptide is administered systemically, preferably parenterally, and wherein the polypeptide is adapted to be targeted to the central nervous system.
Polypeptide comprising the sequence of SEQ ID No. 3 and/or a sequence being at least 80% identical to SEQ ID No. 3 for use in the treatment of neural diseases or neurovascular diseases,
- wherein the polypeptide is administered systemically, preferably parenterally, and wherein the polypeptide is adapted to be targeted to the central nervous system,
- preferably for use in the treatment of Alzheimer's disease.
Dependencies are inferred from the claim text.