Image synchronization without input clock and data transmission clock in a pulsed hyperspectral, fluorescence, and laser mapping imaging system

A system comprising:

• an emitter for emitting pulses of electromagnetic radiation;
• an image sensor comprising a pixel array for sensing reflected electromagnetic radiation;
• a plurality of bidirectional data pads on the image sensor for outputting image data and receiving configuration data;
• and
• a controller in electronic communication with the image sensor and the emitter;
• wherein at least a portion of the plurality of pulses of electromagnetic radiation emitted by the emitter comprises visible and non-visible electromagnetic radiation for eliciting a spectral response from a tissue and further comprises one or more of:
• electromagnetic radiation in a laser mapping pattern;
• or
• a fluorescence excitation wavelength of electromagnetic radiation;
• wherein the controller synchronizes operations of the image sensor and the emitter such that the image sensor outputs data corresponding with the plurality of pulses of electromagnetic radiation emitted by the emitter.