Heteroaromatic derivatives having serotonin receptor binding activity

A composition for serotonin 5-HT2A receptor inverse agonism comprising a compound represented by Formula (I):

• wherein R1 is substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl;
• R2 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R3 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• n is 1 or 2;
• R4 is substituted or unsubstituted non-aromatic nitrogen-containing heterocyclyl;
• L is —NR8—, —O—, or a single bond;
• R8 is a hydrogen atom or substituted or unsubstituted alkyl;
• R5 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• R6 is each independently a hydrogen atom, halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• p is 1 or 2;
• R7 is a group represented by Formula:
• wherein R9 is a hydrogen atom, halogen, substituted or unsubstituted alkyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted amino, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkyl;
• R10 is a hydrogen atom, hydroxy, halogen or substituted or unsubstituted alkyl;
• or
• R9 and R10 are taken together to form a substituted or unsubstituted non-aromatic heterocycle;
• R11 is halogen, hydroxy, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy;
• m is 0 or 1,
• provided that the following compounds (i) and (ii) are excluded:
• (i) a compound wherein L is a single bond, and R1 is substituted or unsubstituted furyl, or substituted or unsubstituted thienyl;
• (ii) a compound wherein L is —NR8—, and R1 is substituted or unsubstituted 2,3-dihydrobenzofuryl;
• or a pharmaceutically acceptable salt thereof.