Amide compounds as kinase inhibitors, compositions and methods of treatment

A compound of Formula (I):

• wherein:
• Z1 is pyrazole optionally substituted with one or more of the following:
• halo, —OH, —CN, —COOR′, —OR′, —SR′, —OC(O)R′, —NHR′, —NR′R″, —NHC(O)R′, —NHC(O)NR′R″, —C(O)NR′R″, —NS(O)2R′, —S(O)2NR′R″, —S(O)2R′, guanidino, nitro, nitroso, —C1-C6 alkyl, aryl, or —C3-C7 cycloalkyl;
• Z2 is phenyl, pyridine, or pyrazole, wherein the phenyl, pyridine, or pyrazole is optionally substituted with, H, halo, —OH, —CN, —COOR′, —OR′, —OR′OR″, —O(CH2)2NR′R″, —SR′, —OC(O)R′, —NHR′, —NR′R″, —NHC(O)R′, —NHC(O)NR′R″, —C(O)NR′R″, —NS(O)2R′, —S(O)2NR′R″, —S(O)2R′, guanidino, nitro, nitroso, —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, or a 3- to 10-membered heterocycle, and wherein the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, or 3- to 10-membered heterocycle is optionally substituted with one or more of the following:
• halo, —OH, —CN, —COOR′, —OR′, —SR′, —OC(O)R′, —NHR′, —NR′R″, —NHC(O)R′, —NHC(O)NR′R″, —C(O)NR′R″, —NS(O)2R′, —S(O)2NR′R″, —S(O)2R′, guanidino, nitro, nitroso, —C1-C6 alkyl, aryl, or —C3-C7 cycloalkyl, and wherein the R′ or R″ are independently —H, methyl or ethyl;
• R1 is H, —C1-C6 alkyl or —C3-C7 cycloalkyl, wherein the —C1-C6 alkyl or —C3-C7 cycloalkyl is optionally substituted with one or more of the following:
• halo, —OH, —CN, —COOR′, —OR′, —SR′, —OC(O)R′, —NHR′, —NR′R″, —NHC(O)R′, —NHC(O)NR′R″, —C(O)NR′R″, —NS(O)2R′, —S(O)2NR′R″, or —S(O)2R′;
• R is methyl;
• X is a bond or —OR4, wherein R4 is H, —C1-C6 alkyl or —C3-C7 cycloalkyl;
• R2 and R3 are independently H, —C1-C6 alkyl, —C3-C7 cycloalkyl, aryl, C5-C10 membered heterocycle,
• wherein
• the —C1-C6 alkyl, —C3-C7 cycloalkyl, aryl, C5-C10 membered heterocycle is optionally substituted with halo, —OH, —CN, —COOR′, —OR′, —SR′, —OC(O)R′, —NHR′, —NR′R″, —CNR′R″, —NHC(O)R′, —NHC(O)NR′R″, —C(O)NR′R″, —NS(O)2R′, —S(O)2NR′R″, —S(O)2R′, guanidino, nitro, nitroso, —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, or 3- to 11-membered heterocycle, wherein
• the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, or 3- to 11-membered heterocycle is optionally substituted with one or more of the following:
• halo, —OH, —CN, —COOR′, —CH2NR′R″, —OR′, —OR′R″, —SR′, —OC(O)R′, —NHR′, —NR′R″, —NHC(O)R′, —NHC(O)NR′R″, —C(O)NR′R″, —NS(O)2R′, —S(O)2NR′R″, —S(O)2R′, guanidino, nitro, nitroso, —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and wherein
• R5 is —C1-C6 alkyl, —OCH2CH2—, —NR6CH2CH2—, —NC(O)CH2CH2—;
• R6 is H, —C1-C6 alkyl or —C3-C7 cycloalkyl;
• and
• R′ or R″ is independently —H or —C1-C6 alkyl, or R′ and R″ together, optionally attaching to N or O atom, form a 4- to 8-membered cyclic structure.