Keto ester compositions and methods for using same
AssigneeOperade LLC
InventorsJohn N. Catanzaro, Christopher D. Batich
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Abstract
The invention generally relates to keto ester compositions and methods for using the compositions. In one aspect, the invention provides a method for preventing a metabolic-related condition or disorder in a subject, the method comprising the step of providing to the subject an effective amount of at least one keto ester compound or a pharmaceutically acceptable salt thereof, and an effective amount of at least one maltodextrin compound, thereby preventing the metabolic-related condition or disorder. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims20
A method for treating or preventing exacerbation of a postoperative catabolic state in a subject, the method comprising the step of providing to the subject an effective amount of at least one keto ester compound or a pharmaceutically acceptable salt thereof, and an effective amount of at least one maltodextrin compound, thereby treating or preventing the subject from exacerbation of a postoperative catabolic state.
A method for preventing or treating a metabolic-related condition or disorder in a postoperative subject, the method comprising the step of providing to the subject after a surgical procedure an effective amount of at least one keto ester compound or a pharmaceutically acceptable salt thereof, and an effective amount of at least one maltodextrin compound, thereby treating or preventing the a metabolic-related condition or disorder;
- wherein the metabolic-related condition or disorder is associated with surgical stress or fasting, or a combination thereof.
A composition comprising an effective amount of at least one keto ester compound or a pharmaceutically acceptable salt thereof, and an effective amount of at least one maltodextrin compound;
- wherein the at least one keto ester compound is selected from 3-hydroxybutyl 3-hydroxybutanoate, 3-hydroxybutyl (3R)-3-hydroxybutanoate, 3-hydroxybutyl (R)-3-hydroxybutyrate, R-BHB;
- BD-AcAc 2;
- ester ketone, ketone ester;
- (R)—(R)-3-hydroxybutyl 3-hydroxybutanoate;
- [(3R)-3-hydroxybutyl] (3R)-3-hydroxybutanoate;
- (3R)-3-Hydroxybutanoic acid (3R)-3-hydroxybutyl ester;
- Butanoic acid, 3-hydroxy-, (3R)-3-hydroxybutyl ester, analogues and salts thereof;
- and wherein the at least one maltodextrin compound is a polysaccharide comprising D-glucose units connected in chains of variable length.
The composition of claim 20, wherein the at least one keto ester compound is 3-hydroxybutyl (3R)-3-hydroxybutanoate or 3-hydroxybutyl (R)-3-hydroxybutyrate.
Dependencies are inferred from the claim text.