Treating Pulmonary Inflammatory Disease Associated With Covid-19 By Administering Resiniferatoxin
AssigneeBoard of Regents of the University of Nebraska
InventorsAlexis Nahama, Henry Hongjun Ji, Irving H. Zucker, Hanjun Wang
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Abstract
There is disclosed a method for treating pulmonary inflammatory disease comprising administering an effective amount of resiniferatoxin (RTX) by an epidural, peri-ganglionic or intra-ganglionic administration. In some embodiments, the dose of RTX for an adult human is from about 0.1 μg to about 100 μg.
Claims23
A method for treating pulmonary inflammatory disease comprising administering to a subject in need of treatment for pulmonary inflammatory disease an effective amount of resiniferatoxin (RTX) epidurally, peri-ganglionically or intra-ganglionically.
A composition comprising resiniferatoxin (RTX) for use in a method of treating a subject in need of treatment for pulmonary inflammatory disease.
The method or composition for use of any one of the preceding claims, wherein the effective amount of RTX results in improved pulmonary function.
The method or composition for use of any one of the preceding claims, wherein the effective amount of RTX results in reduced lung edema.
The method or composition for use of any one of the preceding claims, wherein the subject is an adult human.
The method or composition for use of any one of the preceding claims, wherein the RTX is administered in a dose of from about 0.1 μg to about 100 μg.
The method or composition for use of any one of the preceding claims, wherein the method comprises epidural administration.
The method or composition for use of any one of the preceding claims, wherein the RTX is administered in a pharmaceutical formulation comprising the RTX and a pharmaceutically acceptable carrier.
The method or composition of any one of the preceding claims, wherein the pulmonary inflammatory disease is selected from the group consisting of acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), pulmonary arterial hypertension (PAH), chronic inflammatory lung disease, pulmonary fibrosis, pulmonary vasculitis, pulmonary sarcoidosis, inflammation and/or infection associated with lung transplantation, acute or lung rejection and/or dysfunction, bronchitis, sinusitis, asthma, cystic fibrosis, bacterial infection, fungal infection, parasite infection, viral infection, bronchiolitis obliterans syndrome (BOS), primary ciliary dyskinesia (PCD), alveolar proteinosis, idiopathic pulmonary fibrosis (IPF), eosinophilic pneumonia, eosinophilic bronchitis, inflammation and/or infection associated with mechanical ventilation, ventilator-associated pneumonia, asbestos-related airway disorder or disease, dust-related airway disorder or disease, silicosis, and radiation or chemical agent-related airway disease or disorder, and any combination thereof.
The method or composition of any one of the preceding claims, wherein the pulmonary inflammatory disease is acute respiratory distress syndrome (ARDS).
The method or composition of any one of the preceding claims, wherein the pulmonary inflammatory disease is chronic obstructive pulmonary disease (COPD).
The method or composition of any one of the preceding claims, wherein the pulmonary inflammatory disease is pulmonary arterial hypertension (PAH).
The method or composition of any one of the preceding claims, wherein the pulmonary inflammatory disease is inflammation and/or infection associated with mechanical ventilation and/or ventilator-associated pneumonia.
The method or composition of any one of the preceding claims, wherein the pulmonary inflammatory disease is associated with COVID-19.
Dependencies are inferred from the claim text.