Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

A compound having Formula (II)

• or a therapeutically acceptable salt thereof, wherein:
• n is 0;
• A1 is C(A2);
• A2, D1, and E1 are H;
• B1 is NHR1;
• Y1 is NO2;
• R1 is methyl, which is substituted with one heterocycloalkyl;
• Z2 is piperazinyl;
• L1 is methylene;
• Z3 is cycloalkenyl substituted with R57A and R57;
• R57A is spiroalkyl;
• and
• R57 is phenyl substituted with one Cl.

A compound having Formula (II)

• or a therapeutically acceptable salt thereof, wherein:
• n is 0;
• A1 is C(A2);
• A2, D1, and E1 are H;
• B1 is OR1 or NHR1;
• Y1 is NO2;
• R1 is methyl, which is substituted with one R10;
• R10 is cycloalkyl or heterocycloalkyl;
• wherein R10 is unsubstituted, further unsubstituted, substituted or further substituted with one or two of independently selected from cycloalkyl, heterocycloalkyl, alkyl, alkoxy, OH, or F;
• Z2 is piperazinyl;
• L1 is methylene;
• Z3 is cycloalkenyl substituted with R57A and R57;
• R57A is spiroalkyl;
• and
• R57 is phenyl substituted with one Cl.