Tricyclic heteroarenes, pharmaceutical compositions containing the same, and methods of using the same

A compound of formula (IA):

• or a pharmaceutically acceptable salt thereof,
• wherein
• each is a single or double bond;
• one, two, or three X groups are N, and the remaining X groups are C;
• each Y is independently N or C;
• each Z is independently N or CH;
• R1 is OH, and R3 is hydrogen, optionally substituted C1-6 alkyl, halogen, or optionally substituted C3-8 cycloalkyl;
• or R1 and R3 combine to form —CR9═N—NH—;
• each R2 is independently absent, hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-8 cycloalkyl, optionally substituted C3-8 cycloalkenyl, optionally substituted C2-9 heterocyclyl, optionally substituted C2-9 heterocyclyl C1-6 alkyl, optionally substituted C6-10 aryl, optionally substituted C1-9 heteroaryl, optionally substituted C1-9 heteroaryl C1-6 alkyl, halogen, cyano, —N(R7)2, —OR7, —C(O)N(R8)2, —SO2N(R8)2, —SO2R7A, or -Q-R7B;
• and R2A and R2B together with the atoms to which they are attached, combine to form ring A;
• or R2 and R2A, together with the atoms to which they are attached, combine to form ring A, and R2B is absent or hydrogen;
• R4 is hydrogen, optionally substituted C1-6 alkyl, halogen, or optionally substituted C3-8 cycloalkyl;
• R5 is hydrogen, halogen, or —N(R7)2;
• R6 is —C(O)NH(R8), —C(O)R7A, or —SO2R7A;
• each R7 is independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl C1-6 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C6-10 aryl, optionally substituted C2-9 heterocyclyl, optionally substituted C1-9 heteroaryl, optionally substituted C1-9 heteroaryl C1-6 alkyl, or —SO2R7A;
• or two R7 groups, together with the atom to which both are attached, combine to form an optionally substituted C2-9 heterocyclyl;
• each R7A is independently optionally substituted C1-6 alkyl, optionally substituted C3-8 cycloalkyl, or optionally substituted C6-10 aryl;
• each R7B is independently hydroxyl, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl, optionally substituted C2-9 heterocyclyl, optionally substituted C1-9 heteroaryl, —N(R7)2, —C(O)N(R8)2, —SO2N(R8)2, —SO2R7A, or optionally substituted alkoxy;
• each R8 is independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkoxyalkyl, optionally substituted C6-10 aryl C1-6 alkyl, optionally substituted C6-10 aryl, optionally substituted C3-8 cycloalkyl, or optionally substituted C1-9 heteroaryl;
• or two R8, together with the atom to which they are attached, combine to form an optionally substituted C2-9 heterocyclyl;
• R9 is hydrogen or halogen;
• ring A is a 5- or 6-membered carbocyclic ring or a 5- or 6-membered heterocyclic ring, wherein A is optionally substituted with 1, 2, 3, or 4 non-hydrogen R2 groups;
• and
• Q is optionally substituted C1-6 alkylene, optionally substituted C2-6 alkenylene, optionally substituted C2-6 alkynylene, optionally substituted C3-8 cycloalkylene, optionally substituted C3-8 cycloalkenylene optionally substituted C6-10 arylene, optionally substituted C2-9 heterocyclylene, or optionally substituted C1-9 heteroarylene;
• wherein each R2 is absent, if attached to Y that is N.