Clinically meaningful and personalized disease progression monitoring incorporating established disease staging definitions

An apparatus for staging a disease having a predefined ordered set of S discrete stage where S is an integer having a value greater than or equal to two, the apparatus comprising:

• at least one electronic processor;
• and
• a non-transitory computer readable medium storing instructions readable and executable by at least one electronic processor to perform a method including:
• for a patient to be staged, receiving patient values for a set of clinical metrics;
• using the received patient values, defining a patient vector in a vector space defined by the set of clinical metrics;
• generating at least one stage value for the patient to be staged based on distances in the vector space between the patient vector and representative vectors in the vector space that represent respective discrete stages of the predefined ordered set of S discrete stages;
• and
• controlling a display device operatively connected with the electronic processor to display the at least one stage value for the patient to be staged.

A method for staging a disease having a predefined ordered set of S discrete stages where S is an integer having a value greater than or equal to two, the method comprising:

• for each discrete stage of the S discrete stages, defining a representative vector for the discrete stage in a vector space defined by a set of clinical metrics based on a set of training patients labeled with the discrete stage and with values for the set of clinical metrics by operations including:
• defining training patient vectors in the vector space corresponding to the respective training patients labeled with the discrete stage by the values for the set of clinical metrics labeling the respective training patients;
• and
• defining the representative vector for the discrete stage in the vector space as a centroid of the constructed training patient vectors in the vector space;
• for a patient to be staged, receiving patient values for the set of clinical metrics;
• generating at least one stage value for the patient to be staged based on distances in the vector space between a patient vector defined in the vector space by the patient values for the set of clinical metrics and the representative vectors for the S discrete stages in the vector space;
• and
• displaying the at least one stage value for the patient to be staged on a display device.