Vaccine for prevention of necrotic enteritis in poultry
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsKenneth ROLAND, Andrew DIAMOS, Hugh MASON
Life of this patent
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Abstract
In certain embodiments, the present invention provides a poultry vaccine comprising an antigenic protein comprising a PlcC protein unit that is operably linked to a peptide linker that is operably linked to a NetB protein unit, where the vaccine is effective in stimulating a protective cellular and/or humoral immune response to C. perfringens. Methods are also provided for making the vaccine and for vaccinating poultry by administering such a vaccine.
Claims8
A method of protecting an avian species from C. perfringens infection comprising administering a vaccine comprising an antigenic protein, wherein the antigenic protein comprises a PlcC protein unit that is operably linked to a peptide linker that is operably linked to a NetB protein unit, wherein the PlcC protein unit, the peptide linker and the NetB protein unit each have an N-terminus and a C-terminus, wherein the C-terminus of the PlcC protein unit is linked to the N-terminus of the peptide linker, wherein the C-terminus of the peptide linker is operably linked to the N-terminus of the NetB protein unit, and wherein the peptide linker has at least 95% sequence identity to SEQ ID NO:
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Dependencies are inferred from the claim text.