Compounds and uses thereof

A compound having the structure of Formula I:

• A-L-B Formula I,
• wherein
• A is:
• wherein
• A1 is a bond between A and L;
• R4 is H, optionally substituted C1-C6 alkyl, optionally substituted C2-C9 alkenyl, optionally substituted C1-C6 heteroalkyl, or optionally substituted C3-C10 carbocyclyl;
• R5 is H, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, or optionally substituted C6-C10 aryl;
• R6a is H, halogen, cyano, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C9 alkenyl, optionally substituted C2-C9 heteroalkenyl, hydroxy, thiol, or optionally substituted amino;
• R6b is H, halogen, cyano, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C9 alkenyl, optionally substituted C2-C9 heteroalkenyl, hydroxy, thiol, or optionally substituted amino;
• or R6a and R6b, together with the carbon atoms to which each is attached, combine to form optionally substituted C6-C10 aryl or optionally substituted C2-C9 heteroaryl;
• s is 0, 1, 2, 3, or 4;
• each R9 is, independently, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C9 alkenyl, optionally substituted C2-C9 heteroalkenyl, hydroxy, thiol, or optionally substituted amino;
• B is:
• wherein
• A2 is a bond between the degradation moiety and the linker,
• v1 is 0, 1, 2, 3, 4, or 5;
• u1 is 1, 2, or 3;
• T1 is a bond or
• R5A is H, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 heteroalkyl;
• each RJ1 is, independently, halogen, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 heteroalkyl;
• JA is absent, O, optionally substituted amino, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 heteroalkyl;
• and
• J is absent, optionally substituted C3-C10 carbocyclylene, optionally substituted C6-C10 arylene, optionally substituted C2-C9 heterocyclylene, or optionally substituted C2-C9 heteroarylene;
• L is:
• A1-(E1)-(F1)-(C3)m-(E3)n-(F2)o1-(F3)o2-(E2)p-A2, Formula II
• wherein
• A1 is a bond between the linker and A;
• A2 is a bond between B and the linker,
• each of m, n, o1, o2, and p is, independently, 0 or 1;
• each of E1 and E2 is, independently, O, S, NRN, optionally substituted C1-19 alkylene, optionally substituted C2-10 alkenylene, optionally substituted C2-10 alkynylene, optionally substituted C2-C10 polyethylene glycol, or optionally substituted C1-10 heteroalkylene;
• E3 is optionally substituted C1-C6 alkylene, optionally substituted C1-C6 heteroalkylene, O, S, or NRN;
• each RN is, independently, H, optionally substituted C1-4 alkyl, optionally substituted C2-4 alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C2-6 heterocyclyl, optionally substituted C6-12 aryl, or optionally substituted C1-7 heteroalkyl;
• C3 is carbonyl, thiocarbonyl, sulphonyl, or phosphoryl;
• and
• each of F1, F2, and F3 is, independently, optionally substituted C3-C10 carbocyclylene, optionally substituted C2-10 heterocyclylene, optionally substituted C6-C10 arylene, or optionally substituted C2-C9 heteroarylene,
• or a pharmaceutically acceptable salt thereof.