Niraparib particles and uses thereof

A method for making niraparib particles, comprising:

• (a) introducing (i) a solution comprising at least one solvent selected from the group consisting of ethanol, methanol, hexafluoroisopropanol (HFIP), or combinations thereof, and at least one solute comprising niraparib or a pharmaceutically acceptable salt thereof into a nozzle inlet, and (ii) a compressed fluid into an inlet of a vessel defining a pressurizable chamber;
• (b) passing the solution out of a nozzle orifice and into the pressurizable chamber to produce an output stream of atomized droplets, wherein the nozzle orifice is located between 2 mm and 20 mm from a sonic energy source located within the output stream, wherein the sonic energy source produces sonic energy with an amplitude between 10% and 100% during the passing, and wherein the nozzle orifice has a diameter of between 20 μm and 125 μm;
• (c) contacting the atomized droplets with the compressed fluid, to cause depletion of the solvent from the atomized droplets, to produce niraparib particles comprising at least 95% niraparib or a pharmaceutically acceptable salt thereof, wherein the niraparib particles have a specific surface area (SSA) of at least 5 m2/g,
• wherein steps (a), (b), and (c) are carried out under supercritical temperature and pressure for the compressed fluid.