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US 2023/0142496 A1Published application
Stem cell biomimetic nanoparticle therapeutic agents and uses thereof
OwnerKe CHENGinventor
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OwnerKe CHENGinventor
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A stem cell biomimetic microparticle and methods of manufacture are provided that comprise a core nanoparticle and an outer layer disposed on the core nanoparticle, the core nanoparticle comprising at least one stem cell-derived secreted factor or a population of stem-cell derived exosomes embedded in a biocompatible polymer core nanoparticle, and an outer layer obtained from a cell membrane. Also provided is a method of treating a pathological condition of a patient by delivering to the patient a composition comprising the stem cell biomimetic microparticle comprising at least one stem cell-derived secreted factor or population of stem cell-derived exosomes embedded in a biocompatible polymer core microparticle and an outer layer derived from red blood cell membranes or platelet membranes disposed on the biocompatible polymer core microparticle.
A stem cell biomimetic microparticle comprising a core nanoparticle and an outer layer disposed on the core nanoparticle, the core nanoparticle comprising at least one stem cell-derived secreted factor or a population of stem-cell derived exosomes embedded in a biocompatible polymer core nanoparticle, and wherein the outer layer is obtained from a cell membrane.
A method of generating a biomimetic microparticle, said method comprising the steps of:
The method of step 19, wherein the aqueous solution comprising the at least one stem cell-derived secreted factor is a stem cell-conditioned culture medium or an aqueous solution of at least one isolated stem cell secreted factor.
The method of step 19, wherein the aqueous solution is a mesenchymal stem cell- or a cardiac stem cell-conditioned culture medium.
The method of step 19, wherein the first polymerizable monomer polymer is poly(lactic-co-glycolic acid) (PLGA).
The method of step 19, wherein step (c) further comprises lyophilizing the polymer microparticles.
A method of treating a pathological condition of a patient by delivering to the patient in need thereof a pharmaceutically acceptable composition comprising a stem cell biomimetic microparticle, wherein the stem cell biomimetic microparticle comprises at least one stem cell-derived secreted factor or population of stem cell-derived exosomes embedded in a biocompatible polymer core microparticle and an outer layer derived from red blood cell membranes or platelet membranes disposed on the biocompatible polymer core microparticle.
Dependencies are inferred from the claim text.