A method to produce an immunoglobulin preparation from c-1 inhibitor depleted plasma
AssigneeTakeda Pharmaceutical Company Limited
InventorsUrsula Mais-Paul, Wolfgang Teschner, Leopold Bruckschwaiger, Lucia Gnauer, Brigitte Talir, Sandra Grand, Geoffrey Pot
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Abstract
Described is a method for preparing an Immunoglobulin G (IgG) enriched fraction from a C1-INH depleted plasma supernatant. Isolation of Immunoglobulin G (IgG) enriched fraction from a C1-INH depleted plasma supernatant provided an alternative starting material for the manufacturing process. In the present invention, C1-INH depleted plasma supernatant is treated with heparin before further processing.
Claims28
A method for preparing an Immunoglobulin G (IgG) enriched fraction from a C1-INH depleted supernatant fraction comprising IgG, the method comprising:
- (a) contacting the C1-INH depleted supernatant fraction with heparin, thereby forming a heparinized fraction;
- and
- (b) isolating IgG from the heparinized fraction, thereby forming an IgG enriched fraction.
A supernatant after C1-inhibitor adsorption fraction comprising IgG, wherein said fraction is a cryo-poor plasma fraction depleted of C1-INH by at least about 70% of total present in the cryo-poor plasma fraction.
Dependencies are inferred from the claim text.