Substituted aryl compound

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,

• wherein
• R1 is
• R7 is
• C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R7a;
• R7a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R7b:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R7b is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R7c:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R7c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R8 is H, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R8a;
• R8a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R8b:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R8b is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R8c:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R8c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R9 is C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R9a;
• R9a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R9b:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R9b is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R9c:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R9c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R10 is C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R10a;
• R10a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R10b:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R10b is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R10c:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R10c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R11, R12, and R13 are independently C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R11a;
• or
• R11 and R12, together with an atom to which they are linked, form 3- to 10-membered heterocyclyl, said 3- to 10-membered heterocyclyl is optionally substituted with one or more R11a;
• R11a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R11b:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R11b is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R11c:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R11c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R2, R3, and R4 are independently H, F, Cl, Br, I, OH, CN, NO2, or the following group optionally substituted with one or more Ra:
• NH2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• Ra is F, Cl, Br, I, OH, CN, ═O, NO2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• L is
• X1, X2, X3, Y2, Y3, and Z1 are independently CR15 or N;
• Y1, Z2, and Z3 are independently O, NH, or S;
• m is 0, 1, or 2;
• R15 is H, F, Cl, Br, I, OH, CN, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R15a;
• said R15a is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• L1 is phenyl, C7-C12 spirocyclyl, C6-C12 fused cyclyl, C5-C12 bridged cyclyl, 7- to 12-membered spiroheterocyclyl, 6- to 12-membered fused heterocyclyl, 3- to 10-membered monocyclic heterocyclyl, or 5- to 12-membered bridged heterocyclyl, said 7- to 12-membered spiroheterocyclyl, 6- to 12-membered fused heterocyclyl, 3- to 10-membered monocyclic heterocyclyl, or 5- to 12-membered bridged heterocyclyl contains 1 to 3 heteroatoms selected from O, N, or S;
• said C7-C12 spirocyclyl, C6-C12 fused cyclyl, C5-C12 bridged cyclyl, 7- to 12-membered spiroheterocyclyl, 6- to 12-membered fused heterocyclyl, 3- to 10-membered monocyclic heterocyclyl, or 5- to 12-membered bridged heterocyclyl is optionally substituted with one or more R28;
• said R28 is F, Cl, Br, I, OH, CN, NO2, or the following group optionally substituted with one or more R28a:
• NH2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R28a is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• W1 and W4 are independently a chemical bond, NR16, or O;
• R16 is H, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R16a;
• said R16a is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R5 is
• 3- to 10-membered heterocyclyl, or 5- to 10-membered heteroaryl;
• said 3- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl is optionally substituted with one or more R20a;
• n is 0 or 1;
• X5 is N or CR21;
• Y5 and Y6 are independently a chemical bond, NH, or CR22;
• Z5 and Z6 are independently O or NR23;
• R17, R18, R25, and R26 are independently H, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy is optionally substituted with one or more R17a;
• R17a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R17b:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R17b is F, Cl, Br, I, OH, CN, or the following group optionally substituted with one or more R17c:
• C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, or C6-C10 aryl;
• R17c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• or
• R17 and R18, together with an atom X5 to which they are linked, form 3- to 10-membered heterocyclyl or C3-C10 cycloalkyl, said 3- to 10-membered heterocyclyl or C3-C10 cycloalkyl is optionally substituted with one or more R17a;
• R20 is the following group optionally substituted with one or more R20a:
• 5- to 10-membered heteroaryl, —C(O)-5- to 10-membered heteroaryl, 5- to 10-membered heterocyclyl, C6-C10 aryl, or —C(O)—C6-C10 aryl;
• R20a is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C1-C10 alkoxy, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• said C1-C10 alkyl, C1-C10 alkoxy, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R20b;
• R20b is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, or C3-C10 cycloalkyl;
• R21, R22, and R27 are independently H, C1-C10 alkyl, or C6-C10 aryl, said C1-C10 alkyl or C6-C10 aryl is optionally substituted with one or more R21a;
• R21a is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R23 is H, CN, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl, said C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl is optionally substituted with one or more R23a;
• R23a is F, Cl, Br, I, OH, CN, ═O, NO2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• or
• R4 and R5, together with an atom to which they are linked, form 4- to 6-membered heterocyclyl, phenyl, or 5- to 6-membered heteroaryl, said 4- to 6-membered heterocyclyl, phenyl, or 5- to 6-membered heteroaryl is optionally substituted with one or more R24a;
• R24a is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R24b:
• NH2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R24b is F, Cl, Br, I, OH, CN, ═O, NO2, or the following group optionally substituted with one or more R24c:
• NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy;
• R24c is F, Cl, Br, I, OH, CN, ═O, NO2, NH2, SH, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R6 is H or the following group optionally substituted with one or more R6a:
• NH2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C6-C10 aryl, or 5- to 10-membered heteroaryl;
• R6a is F, Cl, Br, I, OH, CN, ═O, NO2, C1-C10 alkyl, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, C1-C10 alkoxy, C3-C10 cycloalkyloxy, 3- to 10-membered heterocyclyloxy, C2-C10 alkenyl, C2-C10 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C6-C10 aryloxy, or 5- to 10-membered heteroaryloxy,
• provided that when L1 is phenyl, or when R5 is 3- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl, R7 is not