Compounds to Modulate Intestinal Absorption of Nutrients
AssigneeThe Brigham and Women S Hospital, Inc.
InventorsJeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Abstract
This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.
Claims21
1-36. (canceled)
A composition formulated for oral administration to a subject, the composition comprising an acidified aluminum cross-linked sulfated agent and an acid, wherein the composition is in the form of a capsule or a tablet, and wherein the composition includes an enteric coating formulated to release the acidified aluminum cross-linked sulfated agent and acid in at least a portion of the subject's gastrointestinal tract.
A composition formulated for oral administration to a subject, the composition comprising a polymer, a particle stabilizer, and a crosslinking humectant, wherein the composition is in the form of a capsule or a tablet, and wherein, in the presence of acid, the composition forms a mucoadhesive coating on mucosa of at least a portion of the subject's gastrointestinal tract.
Dependencies are inferred from the claim text.