Different forms of 6-chloro-2-ethyl-n-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide
AssigneeQurient Co., Ltd.
InventorsKIYEAN NAM, JAESEUNG KIM, CHUNWON JUNG, SAEYEON LEE
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Abstract
The present invention relates to different forms of the compound 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-l-yl)benzyl)imidazo[l,2-a]pyridine-3-carboxamide and to methods of making such forms/compounds. The present invention furthermore relates to mono-acid addition salts thereof, to methods of making such mono-acid addition salts and to pharmaceutical compositions comprising any of the aforementioned compounds. Furthermore, the present invention relates to uses of any of these compounds.
Claims21
Compound 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide ditosylate having the structure
- and furthermore having at least one of the following peaks in an X-ray Powder Diffraction (XRPD) spectrum obtained by irradiation with Cu-Kα -radiation (Cu-Kα):
- 3.9° 2θ, 5.6° 2θ, 8.0° 2θ, 16.1° 2θ, 19.1° 2θ, and 22.4° 2θ, ± 0.2° 2θ.
A mono-acid addition salt of 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide which is 6-chloro-2-ethyl-N(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide mono-hydrochloride, 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide mono-phosphate, or 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide mono-tosylate.
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Dependencies are inferred from the claim text.