Imidazopyrazine derivatives

A compound of formula (I), or a pharmaceutically acceptable salt thereof,

• wherein:
• Rx is a group
• a group
• or a group
• R1 is selected from R6—C1-C6-alkyl-, R6—C1-C6-alkyl-CH(C1-C6-alkoxycarbonyl)-,
• R7—C1-C6-alkyl-X—C1-C6-alkyl-, a group
• and a group
• and
• R2 is selected from hydrogen and C1-C6-alkyl;
• or R1 and R2, taken together with the nitrogen atom to which they are attached, form a 3- to 14-membered heterocycle that is substituted with R9 and R9a;
• R3 is selected from hydrogen, halogen, and C1-C6-alkyl;
• or
• R3 and R2, taken together with the atoms to which they are attached, form a 3- to 14-membered heterocycle;
• R4 is a group
• R5 is selected from hydrogen, C1-C6-alkyl, and halogen;
• R6 is a group R16-L2-;
• R7 is a group R16-L3-;
• R8 is a group R16-L4-;
• R8a, R9a, R11a, R12, R18, R19, R20, R21, R22, R23, R24, and R25 are independently selected from hydrogen, halogen, hydroxy, cyano, amino, carbamoyl, carboxy, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, cyano-C1-C6-alkyl, carboxy-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkoxy, cyano-C1-C6-alkoxy, C2-C6-alkynyloxy, amino-C2-C6-alkynyloxy, aryloxy, (5- to 14-membered heteroaryl)oxy, C1-C6-alkyl-(5- to 14-membered heteroaryl)oxy, and C1-C6-alkoxycarbonyl;
• R9 is a group R16-L5- or a group
• R10 is selected from C1-C6-alkyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl, C1-C6-alkyl-NH—C1-C6-alkyl, amino-C1-C6-alkyl, carbamoyl, carbamoyl-C1-C6-alkyl, carboxy-C1-C6-alkyl, cyano-C1-C6-alkyl, halo-C1-C6-alkyl, hydroxy-C1-C6-alkyl, and a group
• R11 is selected from C1-C6-alkyl, carbamoyl, carboxy, carboxy-C1-C6-alkyl, and hydroxy-C1-C6-alkyl;
• R13 and R14 are independently selected from C1-C6-alkyl, amino-C1-C6-alkyl, carbamoyl-C1-C6-alkyl, carboxy-C1-C6-alkyl, cyano-C1-C6-alkyl, hydroxy-C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxycarbonyl-C1-C6-alkyl, and a group
• or R13 and R14, taken together with the nitrogen atom to which they are attached, form a 3- to 14-membered heterocycle which is optionally substituted with 1-3 substituents selected from halogen, amino, hydroxy, cyano, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, and halo-C1-C6-alkoxy;
• R15 is C1-C6-alkyl;
• R16 is selected from a group
• a group
• and a group
• R17 is a group R16-L7-;
• L1 is selected from a covalent bond, carbonyl, and —C1-C6-alkyl-;
• L2 and L3 are independently selected from a covalent bond, carbonyl, —C1-C6-alkyl-C(O)—NH—, —C(O)—NH—, —NH—C(O)—, —C(O)—NH—CH(C1-C6-alkoxycarbonyl)-, —C1-C6-alkyl-CH(OH)—C1-C6-alkyl-C(O)—, and —C1-C6-alkyl-NH—;
• L4, L5, L6, L7, and L8 are independently selected from a covalent bond, carbonyl, —C1-C6-alkyl-, —C1-C6-alkyl-C(O)—, —C1-C6-alkyl-NH—C(O)—, —C1-C6-alkyl-C(O)—NH—, —C1-C6-alkyl-NH—C(O)—C1-C6-alkyl-, —C1-C6-alkyl-C(O)—NH—C1-C6-alkyl-, —C(O)—NH—, —NH—C(O)—, —C(O)—NH—CH(C1-C6-alkoxycarbonyl)-, —C1-C6-alkyl-CH(OH)—C1-C6-alkyl-C(O)—, and —C1-C6-alkyl-NH—;
• L9 is —C1-C6-alkyl- or —C(O)—C1-C6-alkyl-;
• A, C, D, and E are each independently selected from C6-C10-aryl, C3-C10-cycloalkyl, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl;
• B is a 3- to 14-membered heterocycle;
• F is C6-C10-aryl or 5- to 14-membered heteroaryl;
• and
• X is selected from O, S, SO, SO2, NH, and N(C1-C6-alkyl).