Direct in vivo reprogramming using transcription factor etv2 gene for endothelial cell and vessel formation
AssigneeEmory University
InventorsYoung-Sup YOON, Sang Ho Lee, Seongho BAE
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Abstract
This disclosure relates to using a ETV2 gene or gene products including DNA, RNA, mRNA, ETV2 proteins, or protein containing exosomes, to directly reprogram and convert resident non-endothelial cells of host into endothelial cells in situ, i.e., in places of the body or tissue where ETV2 is injected. In certain embodiments, it is contemplated that directly reprogrammed and converted endothelial cells will enhance blood vessel regeneration in the tissues where blood vessels have been damaged.
Claims32
A method of converting non-endothelial cells into endothelial cells comprising administering a nucleic acid or vector encoding transcription factor ETV2 to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells.
A method of converting non-endothelial cells into endothelial cells comprising administering an ETV2 protein or functional fragment thereof to a subject in places of the body or tissue wherein non-endothelial cells in the tissue convert into endothelial cells.
A method of generating blood vessels in a tissue comprising administering a nucleic acid or vector encoding transcription factor ETV2 to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of generating blood vessels in a tissue comprising administering an ETV2 protein or functional fragment thereof to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of enhancing blood vessel regeneration in the tissues where blood vessels have been damaged comprising administering a nucleic acid or vector encoding transcription factor ETV2 to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of enhancing blood vessel regeneration in the tissues where blood vessels have been damaged comprising administering an ETV2 protein or functional fragment thereof to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of producing new blood vessels in tissues comprising administering a nucleic acid or vector encoding transcription factor ETV2 to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of producing new blood vessels in tissues comprising administering an ETV2 protein or functional fragment thereof to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of treating disease requiring revascularization comprising administering a nucleic acid or vector encoding transcription factor ETV2 to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
A method of treating disease requiring revascularization comprising administering an ETV2 protein or functional fragment thereof to a subject in a tissue wherein non-endothelial cells in the tissue convert into endothelial cells and vessels.
Dependencies are inferred from the claim text.