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US 2023/0141382 A1Published application
Compositions for preservation of viral vectors
AssigneeCellular Biomedicine Group, Inc.
InventorsShuqian YU, Junfeng WU, Yuhong XIA, Luyi ZHANG, Li ZHANG, Ting YAN, Ting HAN
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Abstract
Compositions and methods for the preservation and long-term storage of viral vectors such as lentiviral vectors are provided.
Claims20
A preservation composition for preserving viral vectors, comprising a first preservation reagent and a second preservation reagent,
- wherein the first preservation reagent comprises sucrose at a concentration of 100 g/L to 250 g/L, potassium dihydrogen phosphate or sodium dihydrogen phosphate at a concentration of 0.8 mmol/L to 1.2 mmol/L, disodium hydrogen phosphate or dipotassium hydrogen phosphate at a concentration of 2.6 mmol/L-3.2 mmol/L, and sodium chloride at a concentration of 8.5-10 g/L,
- wherein the second preservation reagent comprises sucrose at a concentration of 100 g/L to 250 g/L, albumin at a concentration of 40 g/L to 300 g/L, sodium caprylate or potassium caprylate at a concentration of 4 mmol/L to 20 mmol/L, sodium N-acetyltryptophan or potassium N-acetyltryptophan at a concentration of 4 mmol/L to 20 mmol/L, potassium dihydrogen phosphate or sodium dihydrogen phosphate at a concentration of 0.1 mmol/L-1.2 mmol/L, disodium hydrogen phosphate or dipotassium hydrogen phosphate at a concentration of 0.5 mmol/L-3 mmol/L, and sodium chloride at a concentration of 1.5-10 g/L.
Dependencies are inferred from the claim text.