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US 2023/0141034 A1Published application
Adamantane-1-carbonyl thiourea, as p2x receptor antagonist
AssigneeComsats University Islamabad
InventorsJamshed IQBAL, Abid MAHMOOD
Life of this patent
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Abstract
Present invention is directed to Adamantane-1-carbonyl thioureas of formula I, Wherein, R is selected from 2-OH, 3-OH, 4-OH, 3,5 diCl, 4-OH, 3-CF3, 5-Br, (2-Cl, pyridine-3-yl), 3-SO2NH2, 2-Cl, 5-NO2, 2-OCH3, 3-OCH3, 4-OCH3, 3,4-diOCH3, 4-Br, 2-Br,4-CH3, 2-CH3, 4-Br, Quinolin-8-yl, 2-Br-4-isopropyl, and 3-(Dimethylamino)propane-1-yl, and their use as P2X Receptor Antagonist for the treatment of inflammation, pain, osteoporosis, neurodegenerative disorders, spinal card injury, hypertension, or urinary incontinence.
Claims5
A compound of formula (I)
- Wherein, R is selected from
- 2-OH,
- 3-OH,
- 4-OH,
- 3,5 diCl, 4-OH,
- 3-CF3, 5-Br,
- (2-Cl, pyridine-3-yl),
- 3-SO2NH2,
- 2-Cl, 5-NO2,
- 2-OCH3,
- 3-OCH3,
- 4-OCH3,
- 3,4-diOCH3,
- 4-Br,
- 2-Br,4-CH3,
- 2-CH3, 4-Br,
- Quinolin-8-yl,
- 2-Br-4-isopropyl, and
- 3-(Dimethylamino)propane-1-yl.
16 more elements
Dependencies are inferred from the claim text.