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US 2023/0140977 A1Published application
Spatial feature analysis for digital pathology images
AssigneeGenentech, Inc.
InventorXiao LI
Life of this patent
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AssigneeGenentech, Inc.
InventorXiao LI
Estimating the term…
Systems and methods relate to processing digital pathology images. More specifically, depictions of objects of a first class (e.g., lymphocytes) and depictions of objects of a second class (e.g., tumor cells) are detected. Locations of each biological object depiction are identified, which are used to generate multiple spatial-distribution metrics that characterize where depictions of objects of a first class are located relative to objects of a second class. The spatial-distribution metrics are used to generate a result corresponding to a predicted biological state of or a potential treatment of a subject. For example, the result may predict whether and/or an extent to which lymphocytes have infiltrated a tumor, whether checkpoint blockade therapy would be an effective treatment for the subject, and/or whether a subject is eligible for a clinical trial.
A computer-implemented method comprising, by a digital pathology image processing system:
A system comprising:
One or more computer-readable non-transitory storage media including instructions that, when executed by one or more data processors, cause the one or more data processors to performed operations comprising:
Dependencies are inferred from the claim text.