Composition and methods for improving heart function and treating heart failure
AssigneeThe Trustees of the University of Pennsylvania
InventorsBenjamin L. Prosser, Kenneth B. Margulies, Alexey Bogush
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Abstract
A recombinant viral vector comprising an expression cassette which comprises a coding sequence for an shRNA inhibitor of vasohibin (VASH)-small vasohibin binding protein (SVBP) complex operably linked to regulatory sequences which direct expression thereof is provided. Further provided are compositions containing such viral vectors formulated for delivery to a human patient. Also provided are methods using these vectors and compositions for improving or stabilizing cardiac function.
Claims23
A replication-defective vector useful for treating patients having heart failure comprising an expression cassette which comprises a coding sequence for an inhibitor of vasohibin (VASH)-small vasohibin binding protein (SVBP) complex operably linked to regulatory sequences which direct expression thereof.
19-24. (canceled)
A method for treating failing human cardiomyocytes comprising delivering to a patient a replication-defective vector according to claim which comprises an expression cassette which comprises a coding sequence for an inhibitor of vasohibin (VASH)-small vasohibin binding protein (SVBP) complex operably linked to regulatory sequences which direct expression thereof.
Dependencies are inferred from the claim text.