Back to results
US 2023/0139593 A1Published application
Treatment of disorders associated with oxidative stress and compounds for same
AssigneesThe University of Adelaide, Board of Regents, The University of Texas System
InventorsThomas Avery, Andrew Abell, Dion Turner, Peter M. Grace, Jiahe Li
Life of this patent
Estimating the term…
Abstract
The present invention relates to the treatment of disorders associated with oxidative stress including neuropathic pain and small synthetically derived compounds for treating such disorders.
Claims27
A method of treating disorders associated with oxidative stress including the step of administering to a subject in need thereof a compound of formula (I):
- wherein
- R1 is selected from C1-C3 alkyl;
- R2 represents:
- where X is selected from OH, OX1, CH2C(O)X2, C(O)X2, CHCHC(O)X2, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino and optionally substituted thio;
- and
- wherein X1 is selected from optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkyl, optionally substituted amino and optionally substituted thio;
- and
- wherein X2 is selected from OH, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino and optionally substituted thio;
- or a pharmaceutically acceptable salt, solvate, or isomer thereof.
6 more elements
A compound of formula (II)
- or a pharmaceutically acceptable salt thereof:
- where R1′ is C1-C3 alkyl and
- where R2′ is selected from:
- a′)
- b′) optionally substituted C2-C10 alkyl
- c′) optionally substituted heterocyclyl
- d′) optionally substituted heteroaryl
- e′)
- f′)
- g′)
- h′)
- and
- i′)
- wherein R3′ is selected from OH, CI, F, CF3, CN, OCF3, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted heteroaryl, optionally substituted aryl, optionally substituted acyl, optionally substituted heterocyclyl, optionally substituted alkenyl, optionally substituted heteroaryloxy, optionally substituted aryloxy, optionally substituted heterocyclyloxy, optionally substituted alkenyloxy, optionally substituted cycloalkyl, optionally substituted cycloalkyloxy, optionally substituted sulfinyl, and optionally substituted sulfonyl;
- m is an integer selected from 1 to 3;
- provided that when m is 1, R3′ is not methyl, OH, NO2 or methoxy;
- R4′ is selected from optionally substituted C4-C8 alkyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocyclyl;
- R5′ is selected from optionally substituted alkyl, optionally substituted C2-C6 alkoxy, optionally substituted heteroaryl, optionally substituted aryl, optionally substituted acyl, optionally substituted heterocyclyl, optionally substituted alkenyl, optionally substituted heteroaryloxy, optionally substituted aryloxy, optionally substituted heterocyclyloxy, optionally substituted alkenyloxy, and optionally substituted cycloalkyl;
- R6′ and R7′ are independently selected from H, optionally substituted C1-C6 alkyl, optionally substituted aryl and optionally substituted arylalkyl;
- provided that when one of R6′ and R7′ is H the other is not benzyl;
- and
- R8′ is selected from optionally substituted alkyl, optionally substituted aryl, and optionally and substituted arylalkyl.
19 more elements
Dependencies are inferred from the claim text.