RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of Use

A method of inhibiting XDH gene expression, reducing XDH mRNA expression level, or reducing XDH protein expression level in a cell comprising:

• contacting an RNAi agent to the cell, thereby inhibiting XDH gene expression, reducing XDH mRNA expression level, or reducing XDH protein expression level in the cell,
• wherein the RNAi agent comprising a sense strand and an antisense strand, wherein the sense strand comprises a nucleic acid sequence of ccuccgcaCfAfGfauauugucau (SEQ ID NO:
• 1664) and the antisense strand comprises a nucleic acid sequence of asUfsgsAfcaauaucUfgUfgCfggagsg (SEQ ID NO:
• 1081), wherein lower case (n)=2′-O-Me modified nucleotide;
• Nf=2′-F modified nucleotide;
• and s=phosphorothioate backbone modification.