Method for Determining a Measure of a Rate of Decay and Mass Spectrometry System
AssigneeThermo Fisher Scientific (Bremen) GmbH
InventorsKyle FORT, Alexander Makarov, Konstantin Ayzikov
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Abstract
Methods and systems for determining a measure of a rate of decay of an ion sample. Specifically, the present disclosure provides methods and apparatus for determining decay constants and cross-section measurements in parallel to mass measurement and decay time correction. The disclosure particularly relates to methods and apparatus for performing Fourier transform mass spectrometry (FTMS).
Claims24
Non-transitory computer readable media storing instructions that, when executed on a processor, cause the performance of a method for determining a measure of a rate of decay of an ion sample undergoing mass analysis in a mass analyser with image current detection, the method comprising:
- receiving a detection signal for the ion sample from a transient detection of the ion sample obtained using the mass analyser, the detection signal for the ion sample having a rate of decay over time;
- and
- determining the measure of the rate of decay of the ion sample based on an extrapolated resolution for the ion sample, the extrapolated resolution being an expected resolution of the detection signal in conditions in which the rate of decay over time of the detection signal for the ion sample is dominated by collisional effects.
A mass spectrometry system comprising a mass analyser, processor, and a memory storing instructions that, when executed on the processor, cause the performance of a method for determining a measure of a rate of decay of an ion sample undergoing mass analysis in a mass analyser with image current detection, the method comprising:
- receiving a detection signal for the ion sample from a transient detection of the ion sample obtained using the mass analyser, the detection signal for the ion sample having a rate of decay over time;
- and
- determining the measure of the rate of decay of the ion sample based on an extrapolated resolution for the ion sample, the extrapolated resolution being an expected resolution of the detection signal in conditions in which the rate of decay over time of the detection signal for the ion sample is dominated by collisional effects.
A mass spectrometry system for performing mass analysis on an ion sample, comprising:
- a first vacuum region comprising a mass analyser configured to provide a detection signal for the ion sample, the first vacuum region being at a first vacuum level;
- a second vacuum region at a second vacuum level, the first vacuum level being a higher vacuum level than the second vacuum level;
- and
- a fluid connection between the first vacuum region and the second vacuum region, the fluid connection configured selectively to introduce gas from the second vacuum region to the first vacuum region, so as to control the pressure within the first vacuum region.
Dependencies are inferred from the claim text.