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AssigneeGuangzhou N Biomed Co., Ltd.
InventorsLing Chen, Lujie Han, Chenchen Yang, Qian Wang, Bo Liu
Estimating the term…
Disclosed are a novel coronavirus vaccine based on an influenza virus vector and a preparation method thereof. The vaccine can efficiently express two antigens, i.e., its own HA antigen and an exogenous SC2R1 antigen, enabling the vaccine to induce immune responses to the two antigens, thus achieving the purpose of preventing both influenza virus and novel coronavirus, thereby eliminating the impacts of the two major infectious diseases of influenza and novel coronavirus on social economy, etc. at one time. In addition, based on existing mature influenza platform techniques, the influenza vaccine can be prepared and produced on a large scale, and the use of influenza vaccines has a long history and good safety.
A novel coronavirus vaccine based on an influenza virus vector, wherein the vaccine comprises an influenza virus vector loaded with a gene sequence encoding an S protein receptor binding region of a novel coronavirus;
The vaccine according to 1-4, wherein the 3′ end of the nucleotide sequence of the gene encoding the S protein receptor binding region of the novel coronavirus is connected to a truncated fragment of NA gene, and the truncated fragment of the NA gene contains a coding region packaging signal at the 3′ end.
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