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US 2023/0133028 A1Published application
Transgenic mice
AssigneeCrescendo Biologics Limited
InventorsYumin Teng, Joyce Young, Brian McGuinness, Mike Romanos, Marianne Brueggemann
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Abstract
The invention relates to nucleic acid constructs for expression in mice for the reproduction of heavy chain only antibodies and VH domains, transgenic mice, related methods and uses.
Claims35
A vector comprising
- a) at least 10 functional human heavy chain V genes wherein at least 10 functional human heavy chain V genes are in their natural configuration;
- b) at least one human heavy chain D gene and at least one human heavy chain J gene;
- c) a murine C gene which lacks the CH1 exon.
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Dependencies are inferred from the claim text.