Biodegradable polyimidazoliums and oligoimidazoliums
AssigneeNanyang Technological University
InventorsBee Eng Mary CHAN, Surendra Hittanahalli MAHADEVEGOWDA, Wenbin ZHONG, Mallikharjuna Rao LAMBU, Jianghua LI, Zhangyong SI
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Abstract
Disclosed herein are compounds in the form of polymers, oligomers and defined molecules having repeating units that all incorporate repeating units formed from an imidazolium group and a biodegradable chain connected to an adjacent repeating unit. The compounds disclosed herein may have antimicrobial activity and so may be used to treat microbial infection and/or to treat surfaces to prevent microbial infections. Also disclosed herein are methods of forming the compounds.
Claims23
A polymer or oligomer or a pharmaceutically acceptable solvate thereof comprising a first repeating unit comprising an imidazolium group and a biodegradable chain connected to an adjacent repeating unit.
A molecule or a pharmaceutically acceptable solvate thereof comprising:
- a first block of oligomeric repeating units, where each repeating unit comprises an imidazolium group and a non-biodegradable alkyl chain connected to an adjacent repeating unit;
- a second block of oligomeric repeating units, where each repeating unit comprises an imidazolium group and a non-biodegradable alkyl chain connected to an adjacent repeating unit;
- and
- a linking group connecting the first block and the second block together, wherein the linking group comprises one or more biodegradable functional groups.
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Dependencies are inferred from the claim text.