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AssigneeEditForce, Inc.
InventorsMizuho Ichinose, Bernard Gutmann, Yusuke Yagi, Yumi Akaiwa, Yasuka Shimajiri, Takahiro Nakamura
Estimating the term…
A method for converting an editing target C contained in a target RNA to U or an editing target U contained in a target RNA to C is provided. A method for editing a target RNA, which comprises applying an artificial DYW protein containing a DYW domain consisting of any one of the polypeptides a, b, c, and be mentioned below to the target RNA: a. a polypeptide having xa1PGxa1SWIExa3-xa16HP . . . HxaaE . . . Cxa17Xa18CH . . . DYW, having a sequence identity of at least 40% to the sequence of SEQ ID NO: 1, and having a C-to-U/U-to-C editing activity, b. a polypeptide having xb1PGxb2SWWTDxb3-xb16HP . . . HxbbE . . . Cxb17xb18CH . . . DYW, having a sequence identity of at least 40% to the sequence of SEQ ID NO: 2, and having a C-to-U/U-to-C editing activity, c. a polypeptide having KPAxc1Axc2IExc3 . . . HxccE . . . Cxc4xc5CH . . . xc6xc7xc8, having a sequence identity of at least 40% to the sequence of SEQ ID NO: 3, and having a C-to-U/U-to-C editing activity, and be. a polypeptide having xb1PGxb2SWWTDxb3-xb16HP . . . HxccE . . . Cxc4xc5CH . . . Dxbc1xbc2, having a sequence identity of at least 40% to the sequence of SEQ ID NO: 90, and having a C-to-U/U-to-C editing activity (in the sequences, x represents an arbitrary amino acid, and . . . represents an arbitrary polypeptide fragment).
A method for editing a target RNA, the method comprising
A DYW domain consisting of any one of the polypeptides a, b, c, and bc mentioned below:
A method for editing a target RNA, the method comprising:
Dependencies are inferred from the claim text.