Amino lipid compound, preparation method therefor, and application thereof

An amino lipid compound, wherein the amino lipid compound is a compound represented by Formula I:

• wherein:
• R1 and R2 are the same or different from each other, and are each independently selected from the group consisting of C6-C24 alkyl, C6-C24 alkenyl, C6-C24 alkynyl and C4-C24 acyl, wherein the C6-C24 alkyl, the C6-C24 alkenyl, the C6-C24 alkynyl and the C4-C24 acyl are optionally substituted with C1-C6 hydrocarbyl;
• X1 is selected from the group consisting of C, O, S, S═O, S(═O)2 and S—S;
• X2 and X3 are the same or different from each other, and are each independently selected from the group consisting of C, N, O, S, S═O, S(═O)2 and S—S;
• when X1 is C, m=2, and two R6 are the same or different from each other;
• when X1 is O, S, S═O, S(═O)2 or S—S, m=0;
• when X2 is C, n=2, and two R7 are the same or different from each other;
• when X2 is N, n=1;
• when X2 is O, S, S═O, S(═O)2 or S—S, n=0;
• when X3 is C, p=2, and two R8 are the same or different from each other;
• when X3 is N, p=1;
• when X3 is O, S, S═O, S(═O)2 or S—S, p=0;
• R3 and R4 are the same or different from each other, and are each independently selected from C1-C12 alkyl, C2-C12 alkenyl and C2-C12 alkynyl, wherein the C1-C12 alkyl, the C2-C12 alkenyl and the C2-C12 alkynyl are optionally substituted with C1-C6 hydrocarbyl, or R3 and R4 bind to each other to form an optionally substituted 4-10 membered heterocycle containing 1 to 6 heteroatoms selected from nitrogen, sulfur, and oxygen;
• R5 is absent, or R5 is hydrogen or C1-C12 alkyl to provide a quaternary amine;
• R6, R7, R8 are hydrogen or C1-C12 alkyl;
• L is C1-C12 alkylene, C2-C12 alkenylene or C2-C12 alkynylene, wherein the C1-C12 alkylene, the C2-C12 alkenylene and the C2-C12 alkynylene are optionally substituted with one or more substituents selected from the group consisting of hydrocarbyl, carboxyl, acyl and alkoxy, or L is an optionally substituted 4-10 membered heterocycle containing heteroatoms selected from nitrogen, sulfur, and oxygen.