A combination of flavonoids and sphingosine 1 phosphate lyase inhibitors for the treatment of lung inflammation

A pharmaceutical combination of a flavonoid compound and a sphingosine-1-phosphate lyase inhibitor (S1PLI) for simultaneous, separate or sequential administration,

• wherein the flavonoid compound is selected from the group consisting of dihydroquercetin (DHQ), quercetin, astilbin, dihydrokaempferol, butin, eriodictyol, hesperetin, hesperidin, homoeriodictyol, isosakuranetin, naringenin, naringin, pinocembrin, poncirin, sakuranetin, sakuranin, sterubin, epigallocatechin gallate, catechin and epicatechin, and
• wherein the sphingosine-1-phosphate lyase inhibitor (S1PLI) is a compound of Formula I
• wherein
• Z is selected from the group consisting of O, S, and NH;
• Q is
• X is O or NR3;
• each of W, Y, and V is independently selected from the group consisting of CH2, CH, N, NH, O and S;
• R1 is selected from the group consisting of ORA, NHOH, hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted arylalkyl, optionally substituted heteroalkyl, optionally substituted heterocycle, optionally substituted alkylheterocycle, and optionally substituted heterocyclealkyl;
• R2 is selected from the group consisting of ORB, C(O)ORB, hydrogen, halogen, nitrile, optionally substituted hydroxyalkyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted arylalkyl, optionally substituted heteroalkyl, optionally substituted heterocycle, optionally substituted alkylheterocycle, and optionally substituted heterocyclealkyl;
• R3 is selected from the group consisting of ORC, N(RC)2, NHC(O)RC, NHSO2RC, and hydrogen;
• R4 is selected from the group consisting of ORD, OC(O)RD, N(RE)2, hydrogen, halogen, optionally substituted hydroxyalkyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted arylalkyl, optionally substituted heteroalkyl, optionally substituted heterocycle, optionally substituted alkylheterocycle, and optionally substituted heterocyclealkyl;
• each of RA, RB, RC, RD, and RE is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted alkylaryl, optionally substituted arylalkyl, optionally substituted heteroalkyl, optionally substituted heterocycle, optionally substituted alkylheterocycle, and optionally substituted heterocyclealkyl.