Cephalosporin antibacterial compound and pharmaceutical application thereof

A compound of formula (I-2) or a pharmaceutically acceptable salt, stereoisomer, rotamer, tautomer or deuterated compound thereof,

• wherein,
• X is selected from the group consisting of N, CH and C—Cl;
• T is selected from the group consisting of S, S═O, CH2 and O;
• E is selected from the group consisting of
• wherein R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, phenyl, alkylthio, and alkyl optionally substituted with carbamoyl;
• R11 and R12 are each independently selected from the group consisting of hydrogen, carboxyl, and alkyl optionally substituted with carbamoyl;
• and m is an integer from 1 to 5;
• F is a single bond;
• A is selected from the group consisting of alkylene, alkenylene and alkynylene;
• is a quaternary ammonium group containing one or more N atoms and selected from the group consisting of heterocyclyl, fused heterocyclyl, heteroaryl and fused heteroaryl, wherein the heterocyclyl, fused heterocyclyl, heteroaryl and fused heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• G2 is G1 or alkylene, wherein the alkylene is optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy and alkylthio;
• G1 is
• wherein each x is independently an integer from 1 to 6;
• A1 is selected from the group consisting of a single bond, alkylene, alkenylene and alkynylene, wherein the alkylene, alkenylene and alkynylene are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy and alkylthio;
• A2 is selected from the group consisting of a single bond, alkylene, alkenylene and alkynylene, wherein the alkylene, alkenylene and alkynylene are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy and alkylthio;
• ring D3 is selected from the group consisting of cycloalkyl, fused cycloalkyl, heterocyclyl and fused heterocyclyl;
• R9 is selected from the group consisting of alkyl, halogen, hydroxy, mercapto, oxo, thio, —NRiRj, —C(O)Rk, —C(O)ORk, nitro, cyano, alkoxy and alkylthio, wherein the alkyl, alkoxy and alkylthio are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• k1 is an integer from 0 to 8;
• C2 is selected from the group consisting of —NR31—C(═O)—, —NR3—C(═O)—R33—, —C(═O)—NR31—, —C(═O)—C(═O)—NR31—, —C(═N—OR32)—C(═O)—NR31—, —NR31—C(═O)—C(═O)—, —NR31—C(═O)—C(═N—OR32)—, —NR3—C(═NH)—, —C(═NH)—NR3—, —NR3—C(═S)—, —C(═S)—NR3—, —NR3—C(═S)—NR3—, —NR3—C(═NH)—NR3—, —NR3— and
• wherein
• each R3 is independently selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy, wherein the alkyl and alkoxy are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj,
• oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• Rm is selected from the group consisting of hydrogen, alkyl, hydroxy, aryl and heteroaryl, wherein the alkyl, aryl and heteroaryl are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, carboxyl, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• each R31 is independently selected from the group consisting of hydroxy, alkyl and alkoxy, wherein the alkyl and alkoxy are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj,
• oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R32 is hydrogen or alkyl;
• R33 is selected from the group consisting of alkylene, alkenylene and alkynylene, wherein the alkylene, alkenylene and alkynylene are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy and alkylthio;
• and ring D2 is heterocyclyl or heteroaryl;
• ring D1 is selected from the group consisting of aryl, fused cycloaryl, heterocyclyl, fused heterocyclyl, heteroaryl and fused heteroaryl;
• each R4 is independently selected from the group consisting of alkyl, halogen, hydroxy, mercapto, oxo, thio, —NRiRj, —C(O)Rk, —C(O)ORk, nitro, cyano, alkoxy and alkylthio, wherein the alkyl, alkoxy and alkylthio are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, —C(O)Rk, —C(O)ORk, —C(S)Rk, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• n is an integer from 0 to 8;
• Ri and Rj are each independently selected from the group consisting of hydrogen, hydroxy, C1-C6 alkyl and C1-C6 alkoxy;
• and
• each Rk is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, alkoxy, hydroxy and —NRiRj, wherein the alkyl, haloalkyl and alkoxy are each independently optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, hydroxy, mercapto, —NRiRj, oxo, thio, carboxyl, nitro, cyano, alkoxy, alkylthio, cycloalkyl, heterocyclyl, aryl and heteroaryl.