Nano-delivery system and therapeutic and diagnostic use thereof
AssigneeNanocarry Therapeutics Ltd.
InventorsRachela POPOVTZER, Oshra BETZER, Menachem MOTIEI
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Abstract
The present invention provides a generic platform for delivering molecules with low blood-brain barrier (BBB) penetration into the brain. The nano-delivery system is based on a core nanoparticle which is conjugated through a first polymeric linker to a brain-internalizing transporter moiety, and is further conjugated to a second polymeric linker bound to an active agent selected rom a biologically active molecule or a labeling molecule. Further provided is a process for preparation of the nano-delivery system. The present invention further provides pharmaceutical compositions comprising the nano-delivery system and its use in therapeutic and/or diagnostic methods.
Claims21
1-40. (canceled)
A nano-delivery system comprising:
- (a) an inorganic nanoparticle bound to a first linear polymeric linker and to a second linear polymeric linker, wherein the first and the second linear polymeric linkers have substantially different lengths;
- (b) a brain internalizing transporter moiety conjugated to the first linear polymeric linker through a first functional end group of the first linear polymeric linker;
- and
- (c) an active agent selected from a biologically active molecule or a labeling molecule, wherein the active agent is conjugated to the second linear polymeric linker through a second functional end group of the second linear polymeric linker;
- wherein the molecular weight of the first linear polymeric linker is higher than the molecular weight of the second linear polymeric linker in at least 1000 Da;
- and
- wherein the molecular weight of the first and the second linear polymeric linkers is within the range of 1,000-10,000 Da.
Dependencies are inferred from the claim text.