Compounds for the Prevention and Treatment of Medical Disorders and Uses Thereof
AssigneeGalectin Sciences, LLC
InventorsRaphael NIR, Eliezer ZOMER, Peter G. TRABER, Joseph M. JOHNSON, Ryan GEORGE, Sharon SHECHTER
Life of this patent
Estimating the term…
Abstract
Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.
Claims37
A compound of Formula I or a pharmaceutically acceptable salt or solvate thereof:
- wherein Y linkage is (-CH=) or (-CH2-) or -CH2-X- wherein X is nitrogen, oxygen, sulfur or selenium;
- wherein Z is a carbon;
- wherein R1 is hydrogen, oxygen, amine, carboxyl, C1-C6 alkyl, C1-C4 alkoxy, aryl, halogen, trifluoromethyl, dinitromethyl or a combination of the foregoing;
- and
- wherein R2, R3 or R2 and R3 are aryl group with one or more substitutions, wherein the one or more substitution is hydroxyl, amine, C1-C6 alkyl, C1-C4 alkoxy, halogen, benzene or combinations thereof.
A compound of Formula I or a pharmaceutically acceptable salt or solvate thereof:
- wherein Y linkage is (-CH=) or (-CH2-) or -CH2-X- wherein X is nitrogen, oxygen, sulfur or selenium;
- wherein Z is a carbon;
- wherein R1 is hydrogen, oxygen, amine, carboxyl, C1-C6 alkyl, C1-C4 alkoxy, aryl, halogen, trifluoromethyl, dinitromethyl or a combination of the foregoing;
- and
- wherein R2, R3 or R2 and R3 are fluoromethyl.
A compound selected from the compounds having the formula
- .
A compound having the formula
- .
A compound of Formula I or a pharmaceutically acceptable salt or solvate thereof:
- wherein Y linkage is (-CH=) or (-CH2-) or -CH2-X- wherein X is nitrogen, oxygen, sulfur or selenium;
- wherein Z is a carbon;
- wherein R1 is hydrogen, oxygen, amine, carboxyl, C1-C6 alkyl, C1-C4 alkoxy, aryl, halogen, trifluoromethyl, dinitromethyl or a combination of the foregoing;
- and
- wherein the compound has a binding affinity of about 5 nM to 20 µM for Galectin-3.
A compound of Formula I or a pharmaceutically acceptable salt or solvate thereof:
- wherein Y linkage is (-CH=) or (-CH2-) or -CH2-X- wherein X is nitrogen, oxygen, sulfur or selenium;
- wherein Z is a carbon;
- wherein R1 is hydrogen, oxygen, amine, carboxyl, C1-C6 alkyl, C1-C4 alkoxy, aryl, halogen, trifluoromethyl, dinitromethyl or a combination of the foregoing;
- and
- wherein the compound binds Galectin 3 with higher specificity than Galectin 1, Galectin 8, Galectin 9 or other galectins.
Dependencies are inferred from the claim text.