Compound and radioactive labeling compound
AssigneesNihon Medi-Physics Co., Ltd., Kyoto University
InventorsYoshifumi MAYA, Masahiro ONO, Shimpei IIKUNI
Life of this patent
Estimating the term…
Abstract
In a compound of the present invention, in a macroscopic view of a chemical structure thereof, a chelating moiety is located at the center of the structure, an atomic group containing an albumin binding moiety binds to one side of the chelating moiety, and an atomic group containing a target molecule binding moiety binds to the other side of the chelating moiety. The chelating moiety is also preferably DOTA or a derivative thereof. The target molecule binding moiety preferably has a structure to bind to a target molecule expressed in a cancer tissue. The present invention also provides a radioactive labeled compound in which the compound is coordinated to a radioactive metal ion.
Claims12
A compound represented by the following formula (1):
- C-A-B (1)
- wherein, A represents a chelating moiety capable of being coordinated to a radioactive metal ion, B represents an atomic group containing an albumin binding moiety, and C represents an atomic group containing a target molecule binding moiety,
- B binds to a site of A, and
- C binds to A at a site different from the site where B binds to A.
Dependencies are inferred from the claim text.