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US 2023/0111666 A1Published application
Therapeutic delivery vesicles
AssigneeEvox Therapeutics Ltd
InventorsSamir EL ANDALOUSSI, Oscar Wiklander, Joel Nordin, Edvard Smith, Karl-Henrik Grinnemo, Oscar Simonson
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Abstract
The present invention pertains to inter alia methods for purifying extracellular vesicles including exposing a sample comprising at least one extracellular vesicle to ultrafiltration; and exposing the sample following the ultrafiltration in step (i) to size exclusion liquid chromatography.
Claims24
A method for purifying extracellular vesicles comprising:
- (i) exposing a sample comprising at least one extracellular vesicle to ultrafiltration;
- and
- (ii) exposing the sample following the ultrafiltration in step (i) to size exclusion liquid chromatography.
A method for purifying extracellular vesicles, comprising:
- (i) introducing at least one polynucleotide construct encoding at least one polypeptide into a cell capable of producing extracellular vesicles;
- (ii) collecting the extracellular vesicles produced by the cell of step (i);
- and
- (iii) purifying the extracellular vesicles collected in step (ii) using ultrafiltration followed by size exclusion liquid chromatography.
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Dependencies are inferred from the claim text.