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US 2023/0107794 A1Published application
Multi Chromophore Fluorescent Dyes with Enhanced Brightness
OwnerYongchao Liang, Yu Cheninventors
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Abstract
Provided are multi-chromophore dyes. Embodiments of the multi-chromophore dyes include two or more dyes each comprising a water solubilizing group, two or more polymeric spacer domains and a linking moiety. Such multi-chromophore dyes can have advantageously high brightness by including multiple dyes while also reducing the rate of self-quenching. Also provided are methods of using such dyes, as well as kits that includes such dyes.
Claims21
A multi-chromophore dye comprising:
- two or more dyes each comprising a water solubilizing group;
- two or more polymeric spacer domains;
- and
- a linking moiety.
1 more element
A method of evaluating a sample for presence of a target analyte, the method comprising:
- (a) contacting the sample with a multi-chromophore dye specific binding member conjugate comprising:
- (i) two or more dyes each comprising a water solubilizing group;
- (ii) two or more polymeric spacer domains;
- and
- (iii) a linking moiety bound to a specific binding member that specifically binds to the target analyte to produce a labeled composition;
- and
- (b) assaying the labeled composition for the presence of a dye conjugated-target analyte binding complex to evaluate whether the target analyte is present in the sample.
4 more elements
21-40. (canceled)
Dependencies are inferred from the claim text.