Charged ion channel blockers and methods for use

A compound represented by Formula (I)

• wherein:
• Y- is a pharmaceutically acceptable anion;
• RF and RG together with the N+ to which they are attached form an optionally substituted heteroaryl ring having zero, one or more heteroatoms in addition to the N+, or an optionally substituted bicyclic heteroaryl ring having zero, one or more heteroatoms in addition to the N+;
• RA, RB, and Rc are each independently selected from H, D halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, nitrile, ORI, NRJRK, NRLC(O)RM, S(O)RN, SO2RO, SO2RORP, SO2NRQRR, SO3RS, CO2RT, C(O)RU, and C(O)NRVRW;
• or RB and vicinal RC together with the carbon atoms to which they are attached form a substituted or unsubstituted 3-7-membered cycloalkyl or a substituted or unsubstituted aryl;
• each of RI, RJ, RK , RL, RM, RN, RO , RP, RQ, RR, RS, RT, RU, RV, and RW is independently selected from H, D, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
• X1 is selected from —CRXRY—, —NRZC(O)—, —NRZC(O)CRXRY—,— OC(O)—, —SC(O)—, —C(O)NR1A—, —C(O)O—, —NRZS(O) —, — S(O)NRZ—, —NRXC(O)NRY—, —(O)CS—, —C(O)—, —S(O)—, and —S(O)2—;
• each of RX, RY, Rz, and R1A is independently selected from H, D, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl;
• and
• each of RD and RE is independently selected from H, D, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, cycloalkyl, aryl, or heteroaryl;
• or RD and RE together with the carbon to which they are attached form a substituted or unsubstituted C3-C7 cycloalkyl or a substituted or unsubstituted heterocyclic ring;
• or RD and RZ together with the carbon and the —N—C(O)—to which they are attached form an optionally substituted 5-8-membered lactam.