Amoebicidal Compositions for Contact Lens Solutions
AssigneeUniversity of the West of Scotland
InventorsFiona Henriquez, Roderick Williams, Ronnie Mooney
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Abstract
Described herein are pharmaceutical compositions and contact lens solutions comprising an Acanthamoeba encystation inhibitor such as a cationic quaternary ammonium compound and a physiologically or pharmaceutically acceptable carrier or excipient, optionally in combination with an Acanthamoeba cytotoxic agent such as an alkylphosphocholine. Such compositions are suitable for use in the treatment of Acanthamoeba infection or the prevention or treatment of Acanthamoeba keratitis.
Claims26
A pharmaceutical composition comprising:
- a) an Acanthamoeba encystation inhibitor;
- b) an Acanthamoeba cytotoxic agent;
- and
- c) a physiologically or pharmaceutically acceptable carrier or excipient.
A contact lens solution comprising:
- a) an Acanthamoeba encystation inhibitor;
- b) an Acanthamoeba cytotoxic agent;
- and
- c) an acceptable carrier or excipient.
A pharmaceutical composition comprising at least one anti-Acanthamoeba agent and a physiologically or pharmaceutically acceptable carrier or excipient, for use in the treatment of Acanthamoeba infection, wherein the anti-Acanthamoeba agent has a structure according to formula (I)
- R1—[Lm]—N+(R2)(R3)(R4) (I)
- wherein
- R1 is an optionally substituted saturated or unsaturated C10-C24 chain;
- L is a linker moiety, wherein m=0 or 1;
- and
- R2, R3 and R4 are independently C1-C4 alkyl substituents (preferably n-alkyl), aryl substituents, or, together with an alkylene moiety of an optional linker L, forms a heterocyclic moiety, whilst optionally one of R2, R3 and R4 may be a straight-chain, unsubstituted aliphatic hydrocarbon chain of up to 22 having a definition corresponding to that of R1.
A contact lens solution comprising at least one anti-Acanthamoeba agent and an acceptable carrier or excipient, wherein the anti-Acanthamoeba agent has a structure according to formula (I)
- R1—[Lm]—N+(R2)(R3)(R4) (I)
- wherein
- R1 is an optionally substituted saturated or unsaturated C10-C24 chain;
- L is a linker moiety, wherein m=0 or 1;
- and
- R2, R3 and R4 are independently C1-C4 alkyl substituents (preferably n-alkyl), aryl substituents, or, together with an alkylene moiety of an optional linker L, forms a heterocyclic moiety, whilst optionally one of R2, R3 and R4 may be a straight-chain, unsubstituted aliphatic hydrocarbon chain of up to 22 having a definition corresponding to that of R1.
Dependencies are inferred from the claim text.