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AssigneesDanmarks Tekniske Universitet, The Trustees of Columbia University in the City of New York
InventorsMorten Otto Alexander Sommer, Mareike Bongers, Harris He Wang, Frank Cusimano
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The invention provides a composition for use as a medicament, comprising cells of a recombinant microorganism capable of producing increased amounts of one or more of 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT) and tryptamine (TRM) as compared to the non-recombinant microorganism from which it was derived. The composition finds use in preventing and/or treating TRM-; 5-HTP-, or 5-HT-related disorders of the central nerve system (CNS); enteric nervous system (ENS); gastro intestine (GI) and metabolism in a mammal, and may be orally administered to a mammal in need thereof. Additionally, a composition comprising cells of a recombinant microorganism capable of producing melatonin is provided for use as a medicament, such as for treatment of depression, dementia, cancer and sleep disorder.
A composition for use as a medicament, wherein said composition comprises cells of a recombinant microorganism, and wherein said microorganism comprises one or more recombinant nucleic acid molecules encoding one or more proteins selected from:
A recombinant bacterial cell comprising one or more recombinant nucleic acid molecules or transgenes encoding one of more proteins selected from:
A method of treating and/or preventing a TRM-;
Dependencies are inferred from the claim text.